The Butterfield Lab

A Muscle Mechanics Laboratory

Our laboratory focuses on the mechanical and physiological properties of muscle tissue during in-vivo ambulation and exercise in a number of models.  We collect direct, real time measurements of mechanical properties and performance of skeletal muscle during modified use, and measure the cellular responses thereafter.  Although it is known that muscle adapts following various modes of exercise, the mechanisms that govern these adaptive processes remain unknown at the cellular level and appear to be related to the mechanical micro-environment of individual fibers within the matrix of skeletal muscle.  The additional contributions of altered muscle function to bone and joint health is of great clinical interest, and we have devised new methodologies to further our understanding of the impact of abnormal muscle function on bone, cartilage, and ligament health during exercise

1.   Waters C, Dupont-Versteegden EE, Kitzman PH, Butterfield TA (2014) Investigating the Mechanisms of Massage Efficacy: the Role of Mechanical Immunomodulation. Journal of Athletic Training. 2014;49(2):266-273.

2.   Waters-Banker C, Butterfield TA, Dupont-Versteegden EE (2014)  Immunomodulatory Effects of Massage on Non-Perturbed Skeletal Muscle in Rats Journal of Applied Physiology.  Jan 15;116(2):164-175. PMCID:PMC3921362

3.   Kerins CM, Moore SD, Butterfield TA, McKeon PM, Uhl TL (2013) Reliability of the Myotonometer for Assessment of the Posterior Shoulder.  International Journal of Sports Physical Therapy. Jun;8(3):248-5. PMCID:PMC3679631

4.   Haas C, Butterfield TA, Abshire S, Zhao Y, , Zhang X,, Jarjoura D, Best TM (2013) Massage timing affects postexercise muscle recovery and inflammation in a rabbit model. Medicine & Science in Sports & Exercise. Jun;45(6):1105-12. PMCID:PMC3632662

5.   Haas C, Butterfield TA, Zhao Y, Zhang X, Jarjoura D, Best TM (2013) Dose-Dependency of Massage on Recovery of Muscle Properties from Eccentric Exercise: Rabbit Study with Clinical Relevance.  British Journal of Sports Medicine. Jan;47(2):83-8

6.   Haas C, Best TM, Qian WangButterfield TA, Zhao Y. (2012) In-Vivo Passive Mechanical Properties of Skeletal Muscle Improve With Massage-Like Loading Following Eccentric Exercise. Journal of Biomechanics. Oct 11;45(15):2630-6. PMCID:PMC3732739

7.   Nam J, Perera PM, Liu J, Rath B, Deschner J, Gassner R, Butterfield TA and Agarwal S. (2011) Sequential Alterations in Catabolic and Anabolic Gene Expression Parallel Pathological Changes during Progression of Monoiodoacetate-induced Arthritis.  PLoS One 6(9): e24320. doi:10.1371/journal.pone.0024320. PMCID: PMC3172226

8.   Nam J, Perera PM, Liu J, Wu L, Rath B, Butterfield TA, Agarwal S. (2011) Transcriptome-wide gene regulation by gentle treadmill walking during the progression of monoiodoacetate induced arthritis Arthritis and Rheumatism Jun;63(6):1613-1625. PMCID: PMC3106131

9.   McMullen C, Butterfield TA, Dietrich M, Andreatta RD, Andrade F, Fry L, Stemple JC. (2011) Chronic Stimulation-Induced Changes in the Rodent Laryngeal Muscle. Journal of Speech, Language and Hearing Research Jun;54:845-853.

10.   Butterfield TA. (2010). Eccentric Exercise In-vivo: Damage and Adaptation in a Stable System.   Exercise and Sport Sciences Reviews, Apr; 38(2): 51-60.

11.  Butterfield TA, Best TM. (2009) Stretch-Activated Ion Channels Are Essential for Functional Adaptations Following Repetitive Eccentric Loading in Skeletal Muscle. Medicine and Science in Sport and Exercise Feb;41(2):351-356.

12.  Zeng H, Butterfield TA, Agarwal S, Haq F, Best TM, Zhao Y. (2008) An Engineering Approach For Quantitative Evaluation of the Lengthwise Strokes In Massage Therapies. ASME Journal of Medical Devices 2(4):10031-10038.

13.  Butterfield TA, Zhao Y, Haq F, Agarwal S, Best TM. (2008) Cyclic Compressive Loading Facilitates Recovery After Eccentric Exercise.  Medicine & Science in Sports & Exercise.  Jul;40(7):1289-1286.

14.  Butterfield TA, Best TM, Merrick MA. (2006). The Dual Role of Neutrophils and Macrophages in Inflammation: A Critical Balance Between Tissue Damage and Repair.  Journal of Athletic Training  41(4): 457-465. PMCID: PMC1748424

15.  Butterfield TA, Herzog W. (2006). Effect of Altering Starting Length and Activation Timing of Muscle on Fiber Strain and Muscle Damage.  Journal of Applied Physiology  100(5):1489-1498.

16.  Butterfield TA, Herzog W. (2006). The Magnitude of Muscle Strain Does Not Influence Serial Sarcomere Number Adaptations Following Eccentric Exercise.  Pflügers Archiv-European Journal of Physiology.Feb;451(5):688-700.

17.  Butterfield TA, Leonard TR, Herzog W. (2005). Differential Serial Sarcomere Number Adaptations in Knee Extensor Muscles of Rats is Contraction Type Dependent.  Journal of Applied Physiology Oct; 99 (4): 1352-1358.

18.  Butterfield TA, Herzog W. (2005). Quantification of Muscle Fiber Strain During In-vivo Repetitive Stretch-Shortening Cycles. Journal of Applied Physiology. Aug; 99 (2): 593-602.

19.  Butterfield, TA, Herzog W. (2005). Is the Force-Length Relationship a Reliable Indicator of Contractile Element Damage Following Eccentric Exercise? Journal of Biomechanics. Sept; 38 (9). 1932-1937.

20.  Longino D, Butterfield TA, Herzog W.  (2005). Frequency and Length Dependent Effects of Botulinum Toxin-Induced Muscle Weakness.  Journal of Biomechanics. Mar; 38 (3): 609-613.