The Butterfield Lab

A Muscle Mechanics Laboratory

Our laboratory focuses on the mechanical and physiological properties of muscle tissue during in-vivo ambulation and exercise in a number of models.  We collect direct, real time measurements of mechanical properties and performance of skeletal muscle during modified use, and measure the cellular responses thereafter.  Although it is known that muscle adapts following various modes of exercise, the mechanisms that govern these adaptive processes remain unknown at the cellular level and appear to be related to the mechanical micro-environment of individual fibers within the matrix of skeletal muscle.  The additional contributions of altered muscle function to bone and joint health is of great clinical interest, and we have devised new methodologies to further our understanding of the impact of abnormal muscle function on bone, cartilage, and ligament health during exercise

Our laboratory focuses on the mechanical and physiological properties of muscle tissue during in-vivo ambulation and exercise in a number of models.  We collect direct, real time measurements of mechanical properties and performance of skeletal muscle during modified use, and measure the cellular responses thereafter.  Although it is known that muscle adapts following various modes of exercise, the mechanisms that govern these adaptive processes remain unknown at the cellular level and appear to be related to the mechanical micro-environment of individual fibers within the matrix of skeletal muscle.  The additional contributions of altered muscle function to bone and joint health is of great clinical interest, and we have devised new methodologies to further our understanding of the impact of abnormal muscle function on bone, cartilage, and ligament health during exercise